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  Health Benefits of Citrus Flavonoids


Citrus Flavonoids enhance Vitamin C and for this reason they should be taken together to supress inflammation and provide pain relief, promote circulation and lower cholesterol & cancer risk.

Citrus Flavonoid Benefits:

  • Enhance Vitamin C Flavonoids enhance the action of vitamin C and for this reason they should be taken together.

  • Inflammation Relief Flavonoids are effectively used in the treatment of arthritis and sport injuries as they are pain relieving. They are also used in relieving pain in the legs and back and can help with gum disease and hemorrhoids.

  • Promotes Circulation Flavonoids improve capillaries, have an antibacterial effect and promote circulation. Helps in the production of bile, lowers blood cholesterol levels and in the prevention and treatment of cataracts.

  • Lowers cholesterol levels

  • Antiaging

  • Protects against infections

  • Counteracts the effects of allergens, chemicals and helps with asthma and allergies

  • Cancer Prevention

The incidence of ovarian cancer may be reduced with increased consumption of dietary flavonoids, according to researchers from Brigham and Women's Hospital and the Harvard School of Public Health. The study looked at food intake surveys and ovarian cancer data from 66,384 participants in the Harvard Nurses' Health Study, which collected health data from 121,700 women over a period of 30 years. This is the first prospective analysis of flavonoid intake and ovarian cancer incidence.

There are 4,000 known flavonoids at this time. Adding citrus flavonoids to your vitamin C is like adding powerful high test racing fuel to your car. Flavonoids destroy free radicals. Flavonoids provide antioxidant protection and suppress inflammation.

Five subclasses of flavonoids:

  • FLAVONOLS: Quercetin, Kaempferol, Myricetin, Isorhamnetin

  • FLAVONES: Luteolin, Apigenin

  • FLAVANONES: Hesperetin, Naringenin, Eriodictyol

  • FLAVAN-3-OLS: (+)-Catechin, (+)-Gallocatechin, (-)-Epicatechin, (-)-Epigallocatechin, (-)-Epicatechin 3-gallate, (-)-Epigallocatechin 3-gallate, Theaflavin, Theaflavin 3-gallate, Theaflavin 3'-gallate, Theaflavin 3,3' digallate, Thearubigins

  • ANTHOCYANIDINS: Cyanidin, Delphinidin, Malvidin, Pelargonidin, Peonidin, Petunidin

The major flavonoids found in citrus fruits are diosmin, hesperidin, rutin, naringin, tangeretin, diosmetin, narirutin, neohesperidin, nobiletin, and quercetin.

Citrus flavonoids and related substances are widely used in Europe to treat diseases of the blood vessels and lymph system, including hemorrhoids, chronic venous insufficiency, leg ulcers, easy bruising, nosebleeds, and lymphedema following breast cancer surgery. These compounds are thought to work by strengthening the walls of blood vessels and have anti-allergy and anti-inflammatory qualities.

Flavonoids are reported to have numerous health benefits. They are the natural pigments in fruits and vegetables. Formerly known as Vitamin P, they enhance absorption of Vitamin C when taken together. Our body cannot produce flavonoids and supplementing is important for good health. They are known to be effective for pain from injuries and are a must for those who bruise because of their abiity to protect and strengthen capillaries.

Flavonoids aid circulation, lower cholesterol and prevent and treat cataracts. Hemorrhoids are reduced using flavonoids.

Rutin is a flavonoid that is structurally similar to quercitin and a broad range of other flavonoids that naturally occur in plant products. Rutin itself has been clinically studied and demonstrated to be of particular interest in its antagonistic effects on cancer cell metabolism. Rutin seems to have a protective effect against the development of cardiovascular disease. Rutin helps those with capillary or venous fragility - easy bruising and a tendency to not heal well.

Rutin seems to possess a preventive effect in diabetes, by slowing the onset of cataract formation, renal complications, and vascular compromise. Rutin seems to be very effective in the treatment of asthma and allergies.

Citrus flavonoids like hesperidin and rutin, taken with at least 1000 mg of Vitamin C, are also effective in relieving menopausal symptoms such as hot flashes.

Accumulated evidence from experimental and epidemiological studies indicates that there is a low risk of degenerative diseases, cardiovascular disease, hypertension, cataract, stroke, and especially cancer in people with a high intake of flavonoids.

FH-60-1 Citrus Bioflavonoid Complex 100 capsules 520mg (200mg Rutin) $12.95

Ultra C is buffered to help prevent the stomach upset many people experience with other brands. Blended with additional Rose Hip extract and 420 mg of bioflavonoids, we feel this is a great value for 200 easy to take capsules. FH-81-7 Ultra C with 420 mg of flavonoids 1000mg 200 Capsules $21.95


877-493-5987 U.S. Toll Free Order Line 9-6 Eastern



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References for Flavonoids:

1. Ross SA, Ziska DS, Zhoa K, et al. Variance of common flavonoids by brand of grapefruit juice. Fitoterapia. 2000;71:154161.

2. Godeberge P. Daflon 500 mg in the treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo. Angiology. 1994;45:574578.

3. Cospite M. Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids. Angiology. 1994;45:566573.

4. Thanapongsathorn W, Vajrabukka T. Clinical trial of oral diosmin (DaflonW) in the treatment of hemorrhoids. Dis Colon Rectum. 1992;35:10851088.

5. Misra MC, Parshad R. Randomized clinical trial of micronized flavonoids in the early control of bleeding from acute internal haemorrhoids. Br J Surg. 2000;87:868872.

6. Ho YH, Tan M, Seow-Choen F. Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids: randomized controlled trial. Dis Colon Rectum. 2000;43:6669.

7. Tsouderos Y. Venous tone: are the phlebotonic properties predictive of a therapeutic benefit? A comprehensive view of our experience with Daflon 500 mg. Z Kardiol. 1991;80(suppl 7):95101.

8. Ihme N, Kiesewetter H, Jung F, et al. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial. Eur J Clin Pharmacol. 1996;50:443447.

9. Guilhou JJ, Dereure O, Marzin L, et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients. Angiology. 1997;48:7785.

10. Guilhou JJ, Fevrier F, Debure C, et al. Benefit of a 2-month treatment with a micronized, purified flavonoidic fraction on venous ulcer healing. A randomized, double-blind, controlled versus placebo trial. Int J Microcirc Clin Exp. 1997;17(Suppl 1):2126.

11. Guilhou JJ, Dereure O, Marzin L, et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients. Angiology. 1997;48:7785.

12. Guilhou JJ, Fevrier F, Debure C, et al. Benefit of a 2-month treatment with a micronized, purified flavonoidic fraction on venous ulcer healing. A randomized, double-blind, controlled versus placebo trial. Int J Microcirc Clin Exp. 1997;17(Suppl 1):2126.

13. Galley P, Thiollet M. A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility. Int Angiol. 1993;12:6972.

14. Pecking AP, Fevrier B, Wargon C, et al. Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer). Angiology. 1997;48:9398.

15. Lee SH, Park YB, Bae KH, et al. Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A: cholesterol acyltransferase in rats. Ann Nutr Metab. 1999;43:173180.

16. Shin YW, Bok SH, Jeong TS, et al. Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. Int J Vitam Nutr Res. 1999;69:341347.

17. Emim JA, Oliveira AB, Lapa AJ. Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. J Pharm Pharmacol. 1994;46:118122.

18. Manuel y Keenoy B, Vertommen J, De Leeuw I. The effect of flavonoid treatment on the glycation and antioxidant status in Type 1 diabetic patients. Diabetes Nutr Metab. 1999;12:256263.

19. Middleton E Jr, Drzewiecki G, Tatum J. The effects of citrus flavonoids on human basophil and neutrophil function. Planta Med. 1987;53:325328.

20. So FV, Guthrie N, Chambers AF, et al. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer. 1996;26:167181.

21. Godeberge P. Daflon 500 mg in the treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo. Angiology. 1994;45:574578.

22. Cospite M. Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids. Angiology. 1994;45:566573.

23. Misra MC, Parshad R. Randomized clinical trial of micronized flavonoids in the early control of bleeding from acute internal haemorrhoids. Br J Surg. 2000;87:868872.

24. Ho YH, Tan M, Seow-Choen F. Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids: randomized controlled trial. Dis Colon Rectum. 2000;43:6669.

25. Thanapongsathorn W, Vajrabukka T. Clinical trial of oral diosmin (DaflonW) in the treatment of hemorrhoids. Dis Colon Rectum. 1992;35:10851088.

26. Guilhou JJ, Dereure O, Marzin L, et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients. Angiology. 1997;48:7785.

27. Ihme N, Kiesewetter H, Jung F, et al. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial. Eur J Clin Pharmacol. 1996;50:443447.

28. Galley P, Thiollet M. A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility. Int Angiol. 1993;12:6972.

29. Miller MJ. Injuries to athletes. Evaluation of ascorbic acid and water soluble citrus bioflavonoids in the prophylaxis of injuries in athletes. Med Times. 1960;88:313316.

30. Meyer OC. Safety and security of Daflon 500 mg in venous insufficiency and in hemorrhoidal disease. Angiology. 1994;45:579584.

31. Buckshee K, Takkar D, Aggarwal N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet. 1997;57:145151.

32. Bracke ME, Depypere HT, Boterberg T, et al. Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer. J Natl Cancer Inst. 1999;91:354359.

33. Strick R, Strissel PL, Borgers S, et al. Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc Natl Acad Sci. 2000;97:47904795.

34. Laurent R, Gilly R, Frileux C. Clinical evaluation of a venotropic drug in man. Example of Daflon 500 mg. Int Angiol. 1988;7:39-43.

35. Danielsson G, Jungbeck C, Peterson K, et al. A randomised controlled trial of micronised purified flavonoid fraction vs placebo in patients with chronic venous disease. Eur J Vasc Endovasc Surg. 2002;23:7376.

36. Manthey JA, Grohmann K, Guthrie N. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem. 2001;8:135153.

37. Cluzan RV, Alliot F, Ghabboun S, et al. Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT. Lymphology. 1996;29:2935.


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