Vitamin C 1000mg with Rose Hips
Vitamin C provides protection against viral infection by strengthening connective tissue and neutralizing toxic substances.
Linus Pauling, Ph.D., was the only person ever to win more than one unshared Nobel prize. In 1968, he stated that people's needs for vitamins and other nutrients vary markedly and that to maintain good health, many people need amounts of nutrients much greater than the Recommended Dietary Allowances (RDAs). He believed that megadoses of certain vitamins and minerals might well be the treatment of choice for some forms of mental illness. He termed this approach "orthomolecular," meaning "right molecule." After that, he steadily expanded the list of illnesses he believed could be influenced by "orthomolecular" therapy and the number of nutrients suitable for such use.
Vitamin C and the Common Cold
In 1970, Pauling announced in Vitamin C and the Common Cold that taking 1,000 mg of vitamin C daily will reduce the incidence of colds by 45% for most people but that some people need much larger amounts. (The RDA for vitamin C is 60 mg.) The 1976 revision of the book, retitled Vitamin C, the Common Cold and the Flu, suggested even higher dosages . A third book, Vitamin C and Cancer (1979) claims that high doses of vitamin C may be effective against cancer. Yet another book, How to Feel Better and Live Longer (1986), stated that megadoses of vitamins "can improve your general health . . . to increase your enjoyment of life and can help in controlling heart disease, cancer, and other diseases and in slowing down the process of aging." Pauling himself reportedly took at least 12,000 mg daily and raised the amount to 40,000 mg if symptoms of a cold appear. He died in August 1994 at the age of 93.
After the age of 65, women face double the risk of stroke (CVA). People with the highest vitamin C intake were 30% less likely to have a stroke than were those with the lowest intake according to a Dutch study. Smokers with the highest C intake cut stroke risk by 70%.
People of retirement age who took supplements of both vitamin E and C daily saw their risk of Alzheimer's disease plummet by almost 80 per cent, a new study shows.
It appears that when the two vitamins are taken in high doses they work together to protect neurons. The use of these antioxidant vitamins may offer an attractive strategy for the prevention of Alzheimer disease. It appears the high dose of vitamin available in individual supplements is what provided the additional protection.
Vitamin supplements - and vitamins E and C - have been touted for years as effective against a host of conditions, including cardiovascular disease and some forms of cancer.
Vitamin C provides protection against viral infection by strengthening connective tissue and neutralizing toxic substances released by phagocytes. Its direct antiviral action appears to be through the suppression of virus replication and the annihilation of virus-infected cells. Research confirms that vitamin C is antiviral, antibacterial and anticancer. It is known that PGE1, a prostaglandin that plays a major role in regulating T cell function, is enhanced by vitamin C. Vitamin C enhances one of the complement enzymes, C1 esterase, without which the entire enzymatic cascade of complement would not occur and non-self cells would not be destroyed. Tests show that taking as little as 1200 mg of vitamin C per day increased T cell activity, while 500 mg per day increased glutathione levels by 50%. Glutathione is extremely important to immune function because it eliminates toxic substances from the body, enhances cellular oxygen and activates enzymatic reactions.
A recent study conducted on residents of the small town of Mount Healthy, OH, supports the immune-enhancing properties of Vitamin C. Over the course of 50 days, more than 400 residents agreed to supplement their regular diets twice daily with 500 mg of vitamin C. At the end of the study, which was conducted during the winter season, 74% of the residents reported no symptoms commonly associated with colds, while 62% reported feeling healthy and vital.
FH-60-0 VITAMIN C PLUS with Rose Hips 1000mg 180 capsules $16.95
FH-69-5 Vitamin C Liquid 10 fl oz $14.95
1000 mg strong plus 100 mg. of Rose Hips concentrate in easy to swallow capsules. At a bargain price - 180 capsules
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Vitamin C References:
1. Oalmann MC, et al. Atherosclerosis in youth: are hypertension and other coronary heart disease risk factors already at work? Pediatr Nephrol 1997 Feb;11(1):99-107.
2. Celermajer DS, et al. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 1994 Aug;24(2):471-6.
3. Siow RC, et al. Vitamin C protects human vascular smooth muscle cells against apoptosis induced by moderately oxidized LDL containing high levels of lipid hydroperoxides. Arterioscler Thromb Vasc Biol 1999 Oct;19(10):2387-94.
4. Frei B. On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc Soc Exp Biol Med 1999 Dec;222(3):196-204.
5. Siow RC, et al. Induction of antioxidant stress proteins in vascular endothelial and smooth muscle cells: protective action of vitamin C against atherogenic lipoproteins. Free Radic Res 1999 Oct;31 (4):309-18.
6. Kanani PM, et al. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans. Circulation 1999 Sep 14;100(11):1161-8
7. Gokce N, et al. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1999 Jun 29;99(25):3234-40
8. Clemetson CA. The key role of histamine in the development of atherosclerosis and coronary heart disease. Med Hypotheses 1999 Jan;52(1):1-8
9. Carr AC, et al. Vitamin C protects against and reverses specific hypochlorous acid- and chloramine-dependent modifications of low-density lipoprotein. Biochem J 2000 Mar 1;346 Pt 2:491-9.
10. Valkonen MM, et al. Vitamin C prevents the acute atherogenic effects of passive smoking. Free Radic Biol Med 2000 Feb 1;28(3):428-36.
11. Jialal I. The effect of antioxidant dietary micronutrients on LDL oxidation: Implications for atherosclerosis prevention. Canadian Journal of Cardiology (Canada) 1993, 9/SUPPL. B (11B-13B).
12. Singh RB, et al. Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian Experiment of infarct survival-3). Am J Cardiol 1996 Feb 1;77(4):232-6.
13. Ness AR, et al. Vitamin C and cardiovascular disease: a systematic review. J Cardiovasc Risk 1996 Dec; 3(6):513-21.
14. Wilkinson IB, et al. Oral vitamin C reduces arterial stiffness and platelet aggregation in humans. J Cardiovasc Pharmacol 1999 Nov;34(5):690-3.
15. Enstrom JE, et al. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992 May;3(3):194-202
16. Azen SP, et al. Effect of supplementary antioxidant vitamin intake on carotid arterial wall intimamedia thickness in a controlled clinical trial of cholesterol lowering. Circulation 1996 Nov 15;94(10):2369-72.
17. Galley HF, et al. Combination oral antioxidant supplementation reduces blood pressure. Clin Sci (Colch) 1997 Apr;92(4):361-5.
18. Mosca L, et al. Antioxidant nutrient supplementation reduces the susceptibility of low density lipoprotein to oxidation in patients with coronary artery disease. J Am Coll Cardiol 1997 Aug;30 (2):392-9.
19. Paolini M, et al. The nature of prooxidant activity of vitamin C. Life Sci 1999;64(23):PL 273-8.
20. Kogan AKh, et al. [The antioxidant protection of the heart by coenzyme Q10 in stable stenocardia of effort]. Patol Fiziol Eksp Ter 1999 Oct-Dec;(4):16-9.
21. Singh RB, et al. Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role. Int J Cardiol 1999 Jan;68(1):23-9.
22. Singh RB, et al. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther 1998 Sep;12(4):347-53
23. Hanaki Y, et al..Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71(8 Suppl):S112-5.
24. Kato T, et al. Reduction in blood viscosity by treatment with coenzyme Q10 in patients with ischemic heart disease. Int J Clin Pharmacol Ther Toxicol 1990 Mar;28(3):123-6
25. Langsjoen PH, et al. Effective and safe therapy with coenzyme Q10 for cardiomyopathy. Klin Wochenschr 1988 Jul 1;66(13):583-90.
26. Siri PW, et al. Vitamins B6, B12, and folate: association with plasma total homocysteine and risk of coronary atherosclerosis. J Am Coll Nutr 1998 Oct;17 (5):435-41.
27. Verhoef P, et al. Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate. Am J Epidemiol 1996 May 1;143(9):845-59.
28. Shimakawa T, et al. Vitamin intake: a possible determinant of plasma homocyst(e)ine among middle-aged adults. Ann Epidemiol 1997 May;7 (4):285-93.
29. Chasan-Taber L, et al. A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians. J Am Coll Nutr 1996 Apr;15(2):136-43
30. Woodside JV, et al. Published erratum appears in Am J Clin Nutr 1998 Sep;68(3):758 Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial. Am J Clin Nutr 1998 May;67(5):858-66
31. Selhub J, et al. Relationship between plasma homocysteine, vitamin status and extracranial carotid-artery stenosis in the Framingham Study population. J Nutr 1996 Apr;126(4 Suppl):1258S-65S.
32. Fenech MF. Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis 1997 JUL;18(7):1329-1336.
33. Verhoef P, et al. Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate. Am J Epidemiol 1996 May 1;143(9):845-59.
34. Bottiglieri T. Folate, vitamin B-12, and neuropsychiatric disorders. Nutr Rev 1996 Dec;54 (12):382-390
35. Young PB, et al. Lipid peroxidation induced in vivo by hyperhomocysteinaemia in pigs. Atherosclerosis 1997 Feb 28;129(1):67-71.
36. Malinow MR, et al. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. N Engl J Med 1998 Apr 9;338(15):1009-15.
37. Ubbink JB, et al.. Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia. Am J Clin Nutr 1993 Jan;57(1):47-53.
38. Ubbink JB, et al. Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia. Am J Clin Nutr 1993 Jan;57(1):47-53.
39. Robinson K, et al. Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation 1995 Nov 15;92(10):2825-30
40. Verhoef P, et al. Folate and coronary heart disease. Curr Opin Lipidol 1998 Feb;9(1):17-22
41. James H Dwyer, et al. Vitamin C Supplement Intake and Progression of Carotid Atherosclerosis. the Los Angeles Atherosclerosis Study American Heart Association meeting presentation March 2000.
42. Kritchevsky SB, et al. Dietary antioxidants and carotid artery wall thickness. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation 1995 Oct 15;92(8):2142-50.
43. Kiechl S, et al. Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck study. Circulation 1997 Nov 18;96 (10):3300-7.
44. Mezzetti A, et al. Increased systemic oxidative stress after elective endarterectomy: relation to vascular healing and remodeling. Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2659-65.
45. Singh RB, et al. Effect of coenzyme Q10 on experimental atherosclerosis and chemical composition and quality of atheroma in rabbits. Atherosclerosis 1999 Feb;148(2):275-82.
46. Koscielny J, et al. The antiatherosclerotic effect of Allium sativum. Atherosclerosis 1999 May;144 (1):237-49.
47. Duell PB, et al. Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease. Curr Opin Lipidol 1997 Feb;8(1):28-34
48. Malinow MR. Plasma homocyst(e)ine and arterial occlusive diseases: a mini-review. Clin Chem 1995 Jan;41(1):173-6.
49. Mar MH, et al. Betaine in wine: answer to the French paradox? Med Hypotheses 1999 Nov;53 (5):383-5.
50. Wang JA, et al. Betaine:homocysteine methyltransferase--a new assay for the liver enzyme and its absence from human skin fibroblasts and peripheral blood lymphocytes. Clin Chim Acta 1991 Dec 31;204(1-3):239-49.
51. Jie KG, et al. Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study. Calcif Tissue Int 1996 Nov;59(5):352-6.
52. Hackam DG, et al. What level of plasma homocyst(e)ine should be treated? Effects of vitamin therapy on progression of carotid atherosclerosis in patients with homocyst(e)ine levels above and below 14 micromol/L. Am J Hypertens 2000 Jan;13 (1 Pt 1):105-10.
53. Khaw KT, et al. Interrelation of VITAMIN C, infection, haemostatic factors, and cardiovascular disease. BMJ 1995 Jun 17;310(6994):1559-63.
54. Gokce N, et al. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1999 Jun 29;99(25):3234-40.
55. Chambers JC, et al. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin c therapy. Circulation 1999 Mar 9;99(9):1156-60.
56. Wilkinson IB, et al. Oral vitamin C reduces arterial stiffness and platelet aggregation in humans. J Cardiovasc Pharmacol 1999 Nov;34(5):690-3.
57. Jeserich M, et al. Vitamin C improves endothelial function of epicardial coronary arteries in patients with hypercholesterolaemia or essential hypertension�assessed by cold pressor testing. Eur Heart J 1999 Nov;20(22):1676-80.
58. Frei B. On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc Soc Exp Biol Med 1999 Dec;222(3):196-204.
59. Nappo F, et al. Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. JAMA 1999 Jun 9;281 (22):2113-8
60. McAuliffe AV, et al. Administration of ascorbic acid and an aldose reductase inhibitor (tolrestat) in diabetes: effect on urinary albumin excretion. Nephron 1998 Nov;80(3):277-84.
61. Solzbach U, et al. Circulation 1997 Sep 2;96(5):1513-9. Vitamin c improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients.
62. Ting HH, et al. VITAMIN C improves endotheliumdependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia. Circulation 1997 Jun 17;95(12):2617-22.
63. Mosca L, et al. Antioxidant nutrient supplementation reduces the susceptibility of low density lipoprotein to oxidation in patients with coronary artery disease. J Am Coll Cardiol 1997 Aug;30 (2):392-9.
64. Levine GN, et al. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1996 Mar 15;93(6):1107-13
65. Fuller CJ, et al. Effect of ascorbate supplementation on low density lipoprotein oxidation in smokers. Atherosclerosis 1996 Jan 26;119(2):139-50.
66. Valkonen MM, et al. Vitamin C prevents the acute atherogenic effects of passive smoking. Free Radic Biol Med 2000 Feb 1;28(3):428-36.
67. Schwille PO, et al. Postprandial hyperinsulinaemia, insulin resistance and inappropriately high phosphaturia are features of younger males with idiopathic calcium urolithiasis: attenuation by Ascorbic acid supplementation of a test meal. Urol Res 1997;25(1):49-58.
68. Zhang J, et al. A single high dose of vitamin C counteracts the acute negative effect on microcirculation induced by smoking a cigarette. Microvasc Res 1999 Nov;58(3):305-11.
69. Purkayastha SS, et al. Effect of vitamin C and E in modulating peripheral vascular response to local cold stimulus in man at high altitude. Jpn J Physiol 1999 Apr;49(2):159-67.
70.Chamiec T, et al. Effects of antioxidant vitamins C and E on signal-averaged electrocardiogram in acute myocardial infarction. Am J Cardiol 1996 Feb 1;77(4):237-41.
71. Weber C, et al. Increased adhesiveness of isolated monocytes to endothelium is prevented by VITAMIN C intake in smokers. Circulation 1996 Apr 15;93 (8):1488-92.
72. Gatto LM, et al. Ascorbic acid induces a favorable lipoprotein profile in women. J Am Coll Nutr 1996 Apr;15(2):154-8.
73. Singh RB, et al. Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian Experiment of infarct survival-3). Am J Cardiol 1996 Feb 1;77(4):232-6
74. Munoz JA, et al. Effect of VITAMIN C on lipoproteins in healthy adults. Ann Med Interne (Paris) 1994;145(1):13-9.
75. Tomoda H, et al. Possible prevention of postangioplasty restenosis by Ascorbic acid. Am J Cardiol 1996 Dec 1;78(11):1284-6.
76. Laskowski H, et al. Mortality and clinical course of patients with acute myocardial infarction treated with streptokinase and antioxidants: mannitol and Ascorbic acid. Int J Cardiol 1995 Mar 3;48(3):235-7.
77. Eriksson J, et al. Magnesium and Ascorbic acid supplementation in diabetes mellitus. Ann Nutr Metab 1995;39(4):217-23.
78. Gilligan DM, et al. Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia. J Am Coll Cardiol 1994 Dec;24(7):1611-7.
79. Cerna O, et al. Plasma lipids, lipoproteins and atherogenic index in men and women administered vitamin c. Cor Vasa 1992;34(3):246-54.
80. Barta E, et al. Protective effect of alpha-tocopherol and L-ascorbic acid against the ischemic-reperfusion injury in patients during open-heart surgery. Bratisl Lek Listy 1991 Mar-Apr;92(3-4):174-83.
81. Salonen JT, et al. Effects of antioxidant supplementation on platelet function: a randomized pairmatched, placebo-controlled, double-blind trial in men with low antioxidant status. Am J Clin Nutr 1991 May;53(5):1222-9.
82. Hornig B, et al. Vitamin c improves endothelial function of conduit arteries in patients with chronic heart failure. Circulation 1998 Feb 3;97(4):363-8.
83. Heitzer T, et al. Antioxidant vitamin c improves endothelial dysfunction in chronic smokers. Circulation 1996 Jul 1;94(1):6-9.
84. Azen SP, et al. Effect of supplementary antioxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lowering. Circulation 1996 Nov 15;94(10):2369-72.
85. Mayer-Davis EJ, et al. Vitamin c intake and cardiovascular disease risk factors in persons with noninsulin-dependent diabetes mellitus. From the Insulin Resistanc Atherosclerosis Study and the San Luis Valley Diabetes Study. Prev Med 1997 May- Jun;26(3):277-83.
86. Calzada C, et al. The influence of antioxidant nutrients on platelet function in healthy volunteers. Atherosclerosis 1997 Jan 3;128(1):97-105.
87. Bostom AG, et al. The effect of high-dose ascorbate supplementation on plasma lipoprotein(a) levels in patients with premature coronary heart disease. Pharmacotherapy 1995 Jul-Aug;15(4):458-64.
88. Jacques PF, et al. Effect of VITAMIN C supplementation on lipoprotein cholesterol, apolipoprotein, and triglyceride concentrations. Ann Epidemiol 1995 Jan;5(1):52-9.
89. Kelly TH, et al. Response patterns and cardiovascular effects during response sequence acquisition by humans. J Exp Anal Behav 1991 Nov;56(3):557-74. 71. Weber C, et al. Increased adhesiveness of isolated monocytes to endothelium is prevented by VITAMIN C intake in smokers. Circulation 1996 Apr 15;93 (8):1488-92.
90. Westhuyzen J, et al. Effect of preoperative supplementation with alpha-tocopherol and ascorbic acid on myocardial injury in patients undergoing cardiac operations. J Thorac Cardiovasc Surg 1997 May;113 (5):942-8.
91. Pryor WA. Vitamin E and heart disease: basic science to clinical intervention trials. Free Radic Biol Med 2000 Jan 1;28(1):141-64.
92. Strong JP, et al. Early lesions of atherosclerosis in childhood and youth: natural history and risk factors. J Am Coll Nutr 1992 Jun;11 Suppl:51S-54S.
93. Strong JP, et al. Early lesions of atherosclerosis in childhood and youth: natural history and risk factors. J Am Coll Nutr 1992 Jun;11 Suppl:51S-54S.
94. Rath M, et al. Hypothesis: lipoprotein(a) is a surrogate for ascorbate. Proc Natl Acad Sci U S A 1990 Aug;87(16):6204-7
95. Rath M, et al. Immunological evidence for the accumulation of lipoprotein(a) in the atherosclerotic lesion of the hypoascorbemic guinea pig. Proc Natl Acad Sci U S A 1990 Dec;87(23):9388-90.
96. Matthias Rath, et al. Unified Theory of Human Cardiovascular Disease Leading the Way to the Abolition of this Disease as a Cause for Human Mortality. Journal of Orthomolecular Medicine (1992; 7: 5-15.).
97. Axel Niendorf, et al. Morphological detection and quantification of lipoprotein(a) deposition in atheromatous lesions of human aorta and coronary arteries. Virchows Archives of Pathological Anatomy, 1990, Number 417, Pages 105-111.
98. Matthias Rath, et al. Nutritional Supplement Program Halts Progression of Early Coronary Atherosclerosis Documented by Ultrafast Computed Tomography. Journal of Applied Nutrition (1996; 48: 68-78).
99. Tanaka H, et al. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study. Arch Surg 2000 Mar;135(3):326-31.
100. Kodama N, et al. Cisternal irrigation therapy with urokinase and ascorbic acid for prevention of vasospasm after aneurysmal subarachnoid hemorrhage. Outcome in 217 patients. Surg Neurol 2000 Feb;53(2):110-7; discussion 117-8.
101. Sinclair S. Male infertility: nutritional and environmental considerations. Altern Med Rev 2000 Feb;5(1):28-38.
102. van Rooij J, et al. Oral vitamins C and E as additional treatment in patients with acute anterior uveitis: a randomised double masked study in 145 patients. Br J Ophthalmol 1999 Nov;83(11):1277-82.
103. Zollinger PE, et al. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet 1999 Dec 11;354(9195):2025-8.
104. Gorton HC, et al. The effectiveness of vitamin C in preventing and relieving the symptoms of virusinduced respiratory infections. J Manipulative Physiol Ther 1999 Oct;22(8):530-3.
105. Vermeer IT, et al. Effect of ascorbic acid and green tea on endogenous formation of N-nitrosodimethylamine and N-nitrosopiperidine in humans. Mutat Res 1999 Jul 16;428(1-2):353-61.
106. Reinhold U, et al. Treatment of progressive pigmented purpura with oral bioflavonoids and ascorbic acid: an open pilot study in 3 patients. J Am Acad Dermatol 1999 Aug;41(2 Pt 1):207-8.
107. Hemila H. Vitamin C supplementation and common cold symptoms: factors affecting the magnitude of the benefit. Med Hypotheses 1999 Feb;52(2):171-8.
108. Curhan GC, et al. Intake of vitamins B6 and C and the risk of kidney stones in women. J Am Soc Nephrol 1999 Apr;10(4):840-5.
109. Johnston CS. Biomarkers for establishing a tolerable upper intake level for vitamin C. Nutr Rev 1999 Mar;57(3):71-7.
110. Jarosz M, et al. Effects of high dose vitamin C treatment on Helicobacter pylori infection and total vitamin C concentration in gastric juice. Eur J Cancer Prev 1998 Dec;7(6):449-54.
111. McAuliffe AV, et al. Administration of ascorbic acid and an aldose reductase inhibitor (tolrestat) in diabetes: effect on urinary albumin excretion. Nephron 1998 Nov;80(3):277-84.
112. de la Fuente M, et al. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 1998 Apr;76(4):373-80.
113. Allard JP, et al. Effects of vitamin E and C supplementation on oxidative stress and viral load in HIVinfected subjects. AIDS 1998 Sep 10;12(13):1653-9
114. Eberlein-Konig B, et al. Phototoxic lysis of erythrocytes from humans is reduced after oral intake of Ascorbic acid and d-alpha-tocopherol. Photodermatol Photoimmunol Photomed 1997 Oct-Dec;13(5-6):173-7
115. Alessio HM, et al. Exercise-induced oxidative stress before and after VITAMIN C supplementation. Int J Sport Nutr 1997 Mar;7(1):1-9.
116. Schwille PO, et al. Postprandial hyperinsulinaemia, insulin resistance and inappropriately high phosphaturia are features of younger males with idiopathic calcium urolithiasis: attenuation by Ascorbic acid supplementation of a test meal. Urol Res 1997;25(1):49-58.
117. VITAMIN C intake and susceptibility to the common cold. Br J Nutr 1997 Jan;77(1):59-72
118. Gustafsson U, et al..The effect of VITAMIN C in high doses on plasma and biliary lipid composition in patients with cholesterol gallstones: prolongation of the nucleation time. Eur J Clin Invest 1997 May;27(5):387-91.
119. Cohen HA, et al. Blocking effect of VITAMIN C in exercise-induced asthma. Arch Pediatr Adolesc Med 1997 Apr;151(4):367-70.
120. Jeng KC, et al. Supplementation with vitamins C and E enhances cytokine production by peripheral blood mononuclear cells in healthy adults. Am J Clin Nutr 1996 Dec;64(6):960-5.
121. Intake of vitamins A, C, and E and postmenopausal breast cancer. Am J Epidemiol 1996 Jul 15;144(2):165-74.
122. Reilly M, et al. Modulation of oxidant stress in vivo in chronic cigarette smokers. Circulation 1996 Jul 1;94(1):19-25.
123. Levy R, et al. VITAMIN C for the treatment of recurrent furunculosis in patients with imparied neutrophil functions. J Infect Dis 1996 Jun;173(6):1502-5.
124. Curhan GC, et al. A prospective study of the intake of vitamins C and B6, and the risk of kidney stones in men. J Urol 1996 Jun;155(6):1847-51.
125. McAlindon ME, et al. Effect of allopurinol, sulphasalazine, and VITAMIN C on aspirin induced gastroduodenal injury in human volunteers. Gut 1996 Apr;38(4):518-24.
126. Jarrar K, et al. [A case-control study for the recognition of nonoccupational risk factors for tumors of the lower urinary tract]. Dtsch Med Wochenschr 1996 Mar 15;121(11):325-30.
127. Boffa MJ, et al. A double-blind, placebo-controlled, crossover trial of oral VITAMIN C in erythropoietic protoporphyria. Photodermatol Photoimmunol Photomed 1996 Feb;12(1):27-30.
128. Waring AJ, et al. Ascorbic acid and total VITAMIN C concentrations in plasma, gastric juice, and gastrointestinal mucosa: effects of gastritis and oral supplementation. Gut 1996 Feb;38(2):171-6.
129. Lonnrot K, et al. The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity. Free Radic Biol Med 1996;21(2):211-7.
130. Nadgrodkiewicz K. [The effect of intravenous Ascorbic acid on urinary 17-hydroxysteroid excretion at an early stage of cerebral stroke]. Neurol Neurochir Pol 1996 Jan-Feb;30(1):49-56.
131. Wang H, et al. Experimental and clinical studies on the reduction of erythrocyte sorbitol-glucose ratios by Ascorbic acid in diabetes mellitus. Diabetes Res Clin Pract 1995 Apr;28(1):1-8.
132. Sharma DC, et al. Correction of anemia and iron deficiency in vegetarians by administration of Ascorbic acid. Indian J Physiol Pharmacol 1995 Oct;39(4):403-6
133. Paolisso G, et al. Metabolic benefits deriving from chronic VITAMIN C supplementation in aged noninsulin dependent diabetics. J Am Coll Nutr 1995 Aug;14(4):387-92.
134. Gastaldello K, et al. Resistance to erythropoietin in iron-overloaded haemodialysis patients can be overcome by Ascorbic acid administration. Nephrol Dial Transplant 1995;10 Suppl 6:44-7.
135. Vaxman F, et al. Effect of pantothenic acid and Ascorbic acid supplementation on human skin wound healing process. A double-blind, prospective and randomized trial. Eur Surg Res 1995;27 (3):158-66.
136. Wang H, et al. [Reduction of erythrocyte sorbitol by Ascorbic acid in patients with diabetes mellitus]. Chung Hua I Hsueh Tsa Chih 1994 Sep;74(9):548- 51, 583.
137. Herbaczynska-Cedro K, et al. Inhibitory effect of vitamins C and E on the oxygen free radical production in human polymorphonuclear leucocytes. Eur J Clin Invest 1994 May;24(5):316-9.
138. Lamm DL, et al. Megadose vitamins in bladder cancer: a double-blind clinical trial. J Urol 1994 Jan;151(1):21-6.
139. Lockwood K, et al. Apparent partial remission of breast cancer in �high risk� patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Mol Aspects Med 1994;15 Suppl:s231-40.
140. Cunningham JJ, et al. VITAMIN C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus. J Am Coll Nutr 1994 Aug;13(4):344-50.
141. Rifici VA, et al. Dietary supplementation with vitamins C and E inhibits in vitro oxidation of lipoproteins. J Am Coll Nutr 1993 Dec;12(6):631-7
142. Levy R, et al. Successful treatment of a patient with recurrent furunculosis by VITAMIN C: improvement of clinical course and of impaired neutrophil functions. Int J Dermatol 1993 Nov;32(11):832-4.
143. Zamah NM, et al. Absence of an effect of high VITAMIN C dosage on the systemic availability of ethinyl estradiol in women using a combination oral contraceptive. Contraception 1993 Oct;48(4):377-91.
144. Cahill RJ, et al. Effects of vitamin antioxidant supplementation on cell kinetics of patients with adenomatous polyps. Gut 1993 Jul;34(7):963-7.
145. Johnston CS, et al. VITAMIN C elevates red blood cell glutathione in healthy adults. Am J Clin Nutr 1993 Jul;58(1):103-5.
146. Roncucci L, et al. Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas. Colorectal Cancer Study Group of the University of Modena and the Health Care District 16. Dis Colon Rectum 1993 Mar;36(3):227-34.
147. Kataoka A, et al. [Intermittent high-dose VITAMIN C therapy in patients with HTLV-I-associated myelopathy]. Rinsho Shinkeigaku 1993 Mar;33(3):282-8
148. Dumitrescu C, et al. Effect of VITAMIN C administration on the ratio between the pro and antioxidative factors. Rom J Endocrinol 1993;31(1-2):81-4.
149. Karduss Urueta A, et al. [Results of the treatment of chronic idiopathic thrombocytopenic purpura with Ascorbic acid]. Gac Med Mex 1993 Jan-Feb;129 (1):23-5.
150. Dawson EB, et al. Effect of Ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril 1992 Nov;58(5):1034-9.
151. Triana Mantilla ME, et al. [The effect of VITAMIN C on the lipolytic activity in type-II diabetics with angiopathy]. Angiologia 1991 Mar-Apr;43(2):77-81.
152. Reed PI, et al. Effect of Ascorbic acid on the intragastric environment in patients at increased risk of developing gastric cancer. IARC Sci Publ 1991; (105):139-42.
153. Beser E. The effects of short-term VITAMIN C on plasma bun, uric acid, cholesterol and triglyceride levels. Acta Med Hung 1991;48(1-2):73-8.
154. Bucca C, et al. Effect of VITAMIN C on histamine bronchial responsiveness of patients with allergic rhinitis. Ann Allergy 1990 Oct;65(4):311-4.
155. Hunt JR, et al. Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women. Am J Clin Nutr 1990 Apr;51(4):649-55.
156. Johnston CS. Effect of a single oral dose of Ascorbic acid on body temperature and trace mineral fluxes in healthy men and women. J Am Coll Nutr 1990 Apr;9(2):150-4.
157. Holmes LG Effects of smoking and/or VITAMIN C on crevicular fluid flow in clinically healthy gingiva. Quintessence Int 1990 Mar;21(3):191-5.
158. Mai J, et al. High dose antioxidant supplementation to MS patients. Effects on glutathione peroxidase, clinical safety, and absorption of selenium. Biol Trace Elem Res 1990 Feb;24(2):109-17.
159. Park E, et al. Effects of multivitamin/mineral supplementation, at nutritional doses, on plasma antioxidant status and DNA damage estimated by sister chromatid exchanges in lymphocytes in pregnant women. Int J Vitam Nutr Res 1999 Nov;69 (6):396-402.
160. Mirvish SS, et al. Effect of ascorbic acid dose taken with a meal on nitrosoproline excretion in subjects ingesting nitrate and proline. Nutr Cancer 1998;31(2):106-10.
161. Howard DJ. Oxidative stress induced by environmental tobacco smoke in the workplace is mitigated by antioxidant supplementation. Cancer Epidemiol Biomarkers Prev 1998 Nov;7(11):981-8.
162. Seven A, et al. Biochemical evaluation of oxidative stress in propylthiouracil treated hyperthyroid patients. Effects of vitamin C supplementation. Clin Chem Lab Med 1998 Oct;36(10):767-70.
163. Girodon F, et al. Effect of a two-year supplementation with low doses of antioxidant vitamins and/or minerals in elderly subjects on levels of nutrients and antioxidant defense parameters. J Am Coll Nutr 1997 Aug;16(4):357-65.
164. Heuser G, et al. Enhancement of natural killer cell activity and T and B cell function by buffered VITAMIN C in patients exposed to toxic chemicals: the role of protein kinase-C. Immunopharmacol Immunotoxicol 1997 Aug;19(3):291-312.
165. Girodon F, et al. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab 1997;41(2):98-107.
166. Liyanage C, et al. Iron absorption from a traditional Sri Lankan weaning food and the enhancing effect of Ascorbic acid in adult male volunteers. Ceylon Med J 1996 Dec;41(4):135-40.
167. Duthie SJ, et al. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res 1996 Mar 15;56(6):1291-5.
168. Pandey DK, et al. Dietary VITAMIN C and betacarotene and risk of death in middle-aged men. Am J Epidemiol 1995 Dec 15;142(12):1269-78.
169. Hunt C, et al. The clinical effects of VITAMIN C supplementation in elderly hospitalised patients with acute respiratory infections. Int J Vitam Nutr Res 1994;64(3):212-9.
170. Johnston CS, et al. Megadose of VITAMIN C delays insulin response to a glucose challenge in normoglycemic adults. Am J Clin Nutr 1994 Nov;60 (5):735-8
171. Bednar C, et al. Nitrate and VITAMIN C from fruits and vegetables: impact of intake variations on nitrate and nitrite excretions of humans. Plant Foods Hum Nutr 1994 Jan;45(1):71-80.
172. Levin ED, et al. Clinical trials using Ascorbic acid aerosol to aid smoking cessation. Drug Alcohol Depend 1993 Oct;33(3):211-23.
173. Maxwell SR, et al. Changes in plasma antioxidant status during eccentric exercise and the effect of vitamin supplementation. Free Radic Res Commun 1993;19(3):191-202.
174. Shah GM, et al. Effects of Ascorbic acid and pyridoxine supplementation on oxalate metabolism in peritoneal dialysis patients. Am J Kidney Dis 1992 Jul;20(1):42-9.
175. Kritchevsky SB, et al. Dietary antioxidants and carotid artery wall thickness. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation 1995 Oct 15;92(8):2142-50.
176. Stephens NG, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996 Mar 23;347(9004):781-6.
177. Gey, KF. Vitamins E plus C and interacting conutrients required for optimal health. A critical and constructive review of epidemiology and supplementation data regarding cardiovascular disease and cancer. Biofactors 1998;7(1-2):113-74.